The Spurs play the Phoenix Suns at the Moody Center on the campus of the University of Texas, where Kevin Durant starred during his lone college season.
It's the first game of a back-to-back that the Spurs will play in Austin, which is about 75 miles northeast of San Antonio. It marks the third consecutive season that the Spurs will play a pair of home games in Austin, which the franchise considers part of its region.
The Spurs play the Detroit Pistons at the Moody Center on Friday.
Wembanyama, the reigning Rookie of the Year and a first-time All-Star, has averaged 24.3 points, 11.0 rebounds, 3.7 assists and a league-leading 3.8 blocks in 46 games for the 23-29 Spurs.